The main characters are: Homer, Marge, Bart, Lisa, and Maggie. There's also a dog named, 'Santa's Little Helper.
In one episode, Stephen Hawking is a character. Stephen Hawking praises the show as 'the best thing on American television." 
Around 2017-2018 controversy erupted over the fact that one if its supporting characters Apu Nahasapeemapetilon perpetuates negative stereotypes towards Indian people & The voice actor Hank Azaria announced that he will address issues about it.